100 & 200 mg preparation:
For non-systemic fungal disease-
- Vulvovaginal candidiasis: 200 mg twice daily for 01 day
- Pityriasis versicolor: 200 mg once daily for 07 days
- Tinea corporis, tinea cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days
- Tinea pedis, tinea manuum: 100 mg once daily for 30 days
- Oropharyngeal candidiasis: 100 mg once daily for 15 days, Increase dose to 200 mg once daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
- Onychomycosis (toenails with or without fingernail involvement): Either 200 mg daily for 3 months or course (pulse) of 200 mg twice daily for 7 days, subsequent courses repeated after 21 days' interval. Fingernails two courses, toenails three courses.
For systemic fungal disease-
- Aspergillosis: 200 mg once daily for 2-5 months Increase dose to 200 mg twice daily in case of invasive or disseminated disease
- Candidiasis: 100-200 mg once daily for 3 weeks-7 months. Increase dose to 200 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 200 mg once daily for 10 weeks
- Cryptococcal meningitis: 200 mg twice daily for 2-6 months
- Histoplasmosis: 200 mg once daily twice daily for 8 months
- Maintenance in AIDS: 200 mg once daily until immune recovery
- Prophylaxis in neutropenia: 200 mg once daily until immune recovery
The dose and duration of treatment for systemic antifungal disease should be adjusted depending on the clinical response.
65 mg & 130 mg preparation:
For non-systemic fungal disease-
- Vulvovaginal candidiasis: 130 mg twice daily for 1 day
- Pityriasis versicolor: 65 mg twice daily for 7 days
- Tinea corporis and tinea cruris: 65 mg daily for 15 days OR 65 mg twice daily for 7 days
- Tinea pedis and tinea manuum: 65 mg once daily for 30 days
- Oropharyngeal Candidiasis: 65 mg once daily for 15 days, increase dose to 65 mg twice daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
- Onychomycosis (toenails with or without fingernail involvement): Either 65 mg twice daily for 3 months or course (pulse) of 130 mg twice daily for 7 days, subsequent courses repeated after 21 days interval. Fingernails two courses, toenails three courses.
For systemic fungal disease-
- Aspergillosis: 65 mg twice daily for 2-5 months.Increase dose to 130 mg twice daily in case of invasive or disseminated disease
- Candidiasis: 65-130 mg once daily for 3 weeks-7 months. Increase dose to 65 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 65 mg twice daily for 10 weeks
- Cryptococcal meningitis: 130 mg twice daily for 2-6 months
- Histoplasmosis: 130 mg once daily-twice daily for 8 months
- Maintenance in AIDS: 65 mg twice daily until immune recovery
- Prophylaxis in neutropenia: 65 mg twice daily until immune recovery
The dose and duration of treatment for systemic anti-fungal disease should be adjusted depending on the clinical response.
50 mg capsule-
For non-systemic fungal disease:
| Indication | Dose & Duration |
| Pityriasis versicolor | Treatment doses:
Children >4 weeks to <12 years old:
- Usual dose: 1.25-2 mg/kg/dose (to a maximum initial dose of 100 mg) given twice daily. Dose should be adjusted based on therapeutic drug monitoring.
- The dose may be increased to 5 mg/kg/dose (to a maximum initial dose of 100 mg) given twice daily for severe infections. The maximum daily dose may be increased based on therapeutic drug monitoring in discussion with the physicians.
- The dose should be rounded to the nearest 50 mg to facilitate administration.
Children ≥12 years old: Usual dose: 50 mg to 100 mg once daily. Dose may be increased to 100 mg twice daily in severe infections.
Prophylaxis doses:
- Children ≥2 years old: 2.5 mg/kg/dose given once daily (to a maximum initial dose of 200 mg daily). Dose should be adjusted based on therapeutic drug monitoring.
|
| Tinea corporis and tinea cruris |
| Tinea pedis and tinea manuum |
| Oropharyngeal Candidiasis |
| Onychomycosis (toenails with or without fingernail involvement) |
For systemic fungal disease:
| Indication | Dose & Duration |
| Aspergillosis | Treatment doses:
Children >4 weeks to <12 years old:
- Usual dose: 1.25-2 mg/kg/dose (to a maximum initial dose of 100 mg) given twice daily. Dose should be adjusted based on therapeutic drug monitoring.
- The dose may be increased to 5 mg/kg/dose (to a maximum initial dose of 100 mg) given twice daily for severe infections. The maximum daily dose may be increased based on therapeutic drug monitoring in discussion with the physicians.
- The dose should be rounded to the nearest 50 mg to facilitate administration.
Children ≥12 years old: Usual dose: 50 mg to 100 mg once daily. Dose may be increased to 100 mg twice daily in severe infections.
Prophylaxis doses:
- Children ≥2 years old: 2.5 mg/kg/dose given once daily (to a maximum initial dose of 200 mg daily). Dose should be adjusted based on therapeutic drug monitoring.
|
| Candidiasis |
| Non-meningeal Cryptococcosis |
| Cryptococcal Meningitis |
| Histoplasmosis |
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