Ariprex Oral Solution Aripiprazole 5 mg/5 ml

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Overview
Reviews

Indications

Ariprex is indicated for-

Schizophrenia
Bipolar disorder
Adjunctive treatment of major depressive disorder
Irritability associated with autistic disorder
Agitation associated with schizophrenia or bipolar mania

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Pharmacology

Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.

Dosage

Schizophrenia: adults

Initial Dose: 10-15 mg/day
Recommended Dose: 10-15 mg/day
Maximum Dose: 30 mg/day

Schizophrenia: adolescents (ages 13-17 years)

Initial Dose: 2 mg/day
Recommended Dose: 10 mg/day
Maximum Dose: 30 mg/day

Bipolar mania: adults: monotherapy

Initial Dose: 15 mg/day
Recommended Dose: 15 mg/day
Maximum Dose: 30 mg/day

Bipolar mania: adults: adjunct to lithium or valproate

Initial Dose: 10-15 mg/day
Recommended Dose: 15 mg/day
Maximum Dose: 30 mg/day

Bipolar mania: pediatric patients (ages 10-17 years): monotherapy or as an adjunct to lithium or valproate

Initial Dose: 2 mg/day
Recommended Dose: 10 mg/day
Maximum Dose: 30 mg/day

As an adjunct to antidepressants for the treatment of major depressive disorder: adults

Initial Dose: 2-5 mg/day
Recommended Dose: 5-10 mg/day
Maximum Dose: 15 mg/day

Irritability associated with autistic disorder: pediatric patients (ages 6-17 years):

Initial Dose: 2 mg/day
Recommended Dose: 5-10 mg/day
Maximum Dose: 15 mg/day

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Administration

Oral formulations: Administer once daily without regard to meals.
IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Interaction

Caution should be exercised when Ariprex is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Ariprex clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Ariprex elimination and cause increased blood levels.

Contraindications

Known hypersensitivity to Aripiprazole.

Side Effects

Vomiting, nausea, akathisia, extrapyramidal disorder, somnolence, sedation, dizziness, insomnia, tremor, restlessness, fatigue, blurred vision, salivary hypersecretion, constipation, pyrexia, drooling, decreased appetite.

Pregnancy & Lactation

Pregnancy category C. It should be avoided during pregnancy. It is recommended that women receiving Aripiprazole should not breast-feed.

Precautions & Warnings

Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events (eg, stroke, transient ischemic attack, including fatalities).

Suicidality & antidepressants: Increased risk of suicidality in children, adolescents, young and adults with major depressive disorder.

Tardive dyskinesia: Discontinue if clinically appropriate.

Metabolic changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain.

Orthostatic hypotension: Use with caution in patients with known cardiovascular or cerebrovascular disease.

Seizures/Convulsions: Use cautiously in patients with a history of seizures.

Use caution when operating machinery.

Overdose Effects

Ariprex at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Ariprex overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.